NewsSadio Mane: We go to Chelsea with a positive mind, searching for the win
The Reds' first fixture of the new calendar year sees them travel to Stamford Bridge in a battle between second and third in the Premier League.
Mane scored twice there last season to give Jürgen Klopp's side a 2-0 victory, and is fully aware of the big challenge that awaits in the 4.30pm GMT kick-off.
The No.10 told Premier League Productions: "It's a very, very tough game, we know it.
"But I think we are capable to win the tough games as well, like we usually did in the past. We are going there with a positive mind, for sure, and go for a positive result.
"We know it won't be easy but it's possible. It's possible to win the game there – why not try to do our best and get the three points and see what might happen?
"I have good memories, especially last year – we went there and won 2-0 and I scored two goals. I always enjoy playing any team.
"As long as I'm healthy and doing my best for the team, I am always grateful and happy and enjoying the game. It's a game which is really enjoyable, so you have to go there and do what you love to do all the time and hopefully to win the game."
Mane and his teammates are looking to deliver a sharp response following the defeat at Leicester City in midweek.
It was a disappointing end to a testing 2021 and the forward hopes the New Year brings a change in fortunes for himself and the team.
He continued: "Obviously it wasn't a good night for us. In this moment, it would have been really important to win and get these three points, but it wasn't the case. You have to accept it and look forward.
"But at the same time, if you want to win the title it would be very important to win this kind of game. If not, it will be very complicated.
"But still, it's early to speak about losing the title. We all know City are far [ahead] a bit, but still everything is possible and we will fight until the end.
"It was a really, really tough year for me especially, and for the team as well. Especially last season, but at the end of the day we got to the top four, which at one moment was our target. We are happy about that.
"Hopefully in 2022 it will be different and will be a very successful year for Liverpool Football Club."
NewsArne Slot on Conor Bradley and Ibrahima Konate injuries
Reaction'A big result' - Caoimhin Kelleher and Alexis Mac Allister on Liverpool 2-0 Real Madrid
Match reportLiverpool beat Real Madrid at Anfield to continue winning streak in Champions League
Gallery28 photos from Anfield as Liverpool defeat Real Madrid in Champions League
Team newsConfirmed Liverpool line-up v Real Madrid