MatchPre-Man Utd stats: Jürgen Klopp can record 300th win as Liverpool manager
Including successes in penalty shootouts, the boss' win tally currently stands at 299 ahead of the quarter-final showdown at Old Trafford.
A goal for the Reds in this tie would also be their 450th as the away team during Klopp's tenure.
Read on for more interesting facts and figures about the 3.30pm GMT kick-off…
The last two occasions Liverpool have beaten United in the FA Cup, they have gone on to reach the final – in 2006 and 2012.
Only four Reds have scored a winning goal against United in the competition – Daniel Cunliffe (1898), Harry Chambers (1921), Peter Crouch (2006) and Dirk Kuyt (2012).
Each of the last nine ties between the sides, dating back to 1960, have been decided by a one-goal margin.
This is the 15th time the clubs have been drawn together in the FA Cup. Only Everton have been paired with Liverpool on more occasions – 19.
The Reds have scored 12 times in their last four trips to Old Trafford – the same total they produced in the 13 visits prior.
The teams have met on March 17 once before, playing out a 1-1 draw at Old Trafford in the second leg of a Europa League last-16 tie back in 2016 that gave Liverpool a 3-1 aggregate victory.
The Reds are unbeaten in the last six games they have played on St. Patrick's Day since a 2-0 loss at CSKA Sofia in 1982.
Liverpool are aiming to reach their 26th FA Cup semi-final.
Klopp has used 25 players for the three FA Cup ties so far this season, with Wataru Endo and Mohamed Salah yet to appear. Only Jarell Quansah has played every minute.
Should Endo feature, it will take the number of players who have been involved in the competition during Klopp's reign to 97.
United are the last team to prevent Liverpool from scoring. Since their goalless league draw in December, Klopp's men have scored in 20 consecutive matches, making it 54 of the last 55 outings.
TicketsBook now: Away tickets and coach travel for Manchester United v Liverpool in WSL
Play nowQuiz: Liverpool's season so far - can you get 10/10?
ColumnMatt Beard: We have to play the game and not the occasion at Everton
Feature'This city and this club has to fight for everything' - six things spotted in 'The Reds Roundtable'
NewsJarell Quansah joins up with senior England squad