InternationalsLuis Diaz scores curler for Colombia, Alisson keeps clean sheet
The attacker opened the scoring after 39 minutes of the contest in Barranquilla with a fine curling effort into the far corner of the net.
Miguel Borja and Mateus Uribe were also on the scoresheet, with Diaz withdrawn in the 84th minute.
The victory keeps Colombia's hopes of reaching Qatar 2022 alive, heading into the final round of qualifiers.
Elsewhere in the CONMEBOL section, Alisson Becker recorded a clean sheet as Brazil beat Chile 4-0, with Fabinho appearing as an 82nd-minute substitute.
Neymar, Vinicius Junior, Philippe Coutinho and Richarlison netted the goals as the Seleção maintained their unbeaten record in World Cup qualifying.
Latest news
Free videoInside Training: Behind the scenes as U21s take part in workout with seniors
GalleryTraining photos: U21s join senior Liverpool stars in Tuesday session
AuctionsBid on match-worn Liverpool shirts from games against Ipswich Town and Brentford
ClubLiverpool FC's new single sign-in process now being rolled out
On saleBook tickets and coach travel for Women's League Cup tie at Newcastle