NewsLFC injury update: Gravenberch, Endo, Nunez, Salah and Szoboszlai
The midfielder will be sidelined with the issue he sustained midway through the first half of Sunday's Carabao Cup final against Chelsea.
Meanwhile, the fitness of Wataru Endo, Darwin Nunez, Dominik Szoboszlai and Mohamed Salah continues to be monitored.
Speaking at his pre-match press conference on Tuesday, Jürgen Klopp said: "What I know is that Ryan is not available, besides all the others who are not available.
"It's a ligament injury, could have been much worse, but bad enough for being ruled out for this game, next game. We will see. So, we need miracles with a few players, so that's why I don't want to rule out for too long.
"But it's touch and go with a lot of players, still with the boys who [were] not available for the final – like Darwin, Mo, Dom. We have to see what they can do today.
"Wataru got a proper knock as well. There we have to see as well. I wouldn't say it's much improved since Sunday but that's how it is."
Play nowCaoimhin Kelleher birthday quiz: Can you get 9/9?
FeatureClinical Harvey, Robbo's 'bullet' and Danns shock - things spotted in Friday's training
MatchSouthampton v Liverpool: Team news
MatchStats: Mo Salah chasing Robbie Fowler record against Southampton
VideoInside Training: Hail and hard work as Liverpool prepare for Southampton trip