NewsDarwin Nunez injury update ahead of Real Madrid
The No.27 was forced to leave the field of play in the second half of Saturday's 2-0 Premier League victory over Newcastle United, making him a doubt for the last-16 tie at Anfield.
Nunez, though, could yet be fit to face Los Blancos in L4 for the first leg of the knockout contest.
"There's a chance," Klopp told his pre-match press conference.
"From all the possible scenarios, apart from being absolutely nothing; that's not the case.
"We have to see how he can deal with the pain [and] when we know that, we make a decision."
Latest news
MatchStats: Mo Salah chasing Robbie Fowler record against Southampton
VideoInside Training: Hail and hard work as Liverpool prepare for Southampton trip
Gallery51 training photos from Liverpool's Friday session in the rain
AcademyPreston v Liverpool: Youth Cup fixture details confirmed
NewsPremier League announces dates for 2025-26 season