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Liverpool's U21s lost their first league fixture of the 2012-13 campaign with a 1-0 defeat at Tottenham.
The young Reds had been on a 14-match unbeaten run but fell on Monday to a goal from Jonathan Obika.
Krisztian Adorjan went close with a free-kick and Conor Coady struck a post but Alex Inglethorpe's side could find no way back into the match.
Spurs lead the way in the Elite Group section, having now won three out of four games.